Tavneos (Avacopan): Uses, Side Effects, Dosage, and Important Safety Information

Are you looking for comprehensive information about Tavneos (avacopan), a prescription medication for rare autoimmune diseases? This article will cover everything you need to know, from its uses and potential side effects to dosage guidelines and crucial safety considerations.

What is Tavneos (Avacopan) and What Does it Treat?

Tavneos, containing the active ingredient avacopan, is an immunosuppressant classified as a complement 5a receptor (C5aR) antagonist. It's a brand-name medication with no generic version currently available.

• Treats ANCA-Associated Vasculitis: Tavneos is specifically prescribed for adults with two types of antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis:

  • Granulomatosis with polyangiitis (formerly Wegener’s granulomatosis)
  • Microscopic polyangiitis

• How it Works: These conditions involve the immune system mistakenly attacking blood vessels, causing inflammation that restricts blood flow to vital organs like the kidneys and lungs. Tavneos works by blocking a protein involved in this immune response, reducing inflammation.

Tavneos is typically prescribed for severe and active cases of these conditions.

Understanding Potential Tavneos Side Effects

Like all medications, Tavneos can cause side effects. It's crucial to be aware of these potential effects and discuss any concerns with your doctor.

Mild Side Effects of Tavneos

These side effects are often temporary and may resolve on their own. Contact your doctor if these become bothersome.

• Diarrhea
• Skin rash
• Fatigue
• Abdominal pain
• Nausea and vomiting
• Headache
• Dizziness
• Tingling or burning sensations
• High blood pressure

Serious Side Effects of Tavneos: What to Watch Out For

While less common, serious side effects can occur. Seek immediate medical attention if you experience any of the following:

• Kidney problems
• Liver problems
• Serious infections
• Allergic Reactions: Although rare, allergic reactions can occur. Mild symptoms like rash warrant a call to your doctor. Severe symptoms like swelling or trouble breathing require immediate emergency medical care (call 911).

Tavneos Dosage and How to Take It

Your doctor will determine the appropriate Tavneos dosage for your specific needs, so please follow their instructions

• Form and Strength: Tavneos comes in 10-milligram (mg) oral capsules.
• Recommended Dosage: The typical dosage is 30 mg (3 capsules) taken twice daily with food.
• Important Instructions:
  • Swallow capsules whole; do not chew or crush them.
  • Take each dose with food.
  • Take one dose in the morning and one in the evening, approximately 12 hours apart, to maintain consistent drug levels in your body.
  • If you miss a dose, skip it and take your next dose at the regular time. Don't double up on doses.

Addressing Common Questions About Taking Tavneos

• How long will I need to take Tavneos? Usually, Tavneos is a long-term treatment.
• How long does Tavneos take to work? The drug starts working after the first dose, but you might not feel it. Your doctor will monitor your progress.

Tavneos Cost and How to Save

The cost of Tavneos can vary. Consider these factors to manage expenses:

• Cost Information and Savings Coupons: Explore resources like Optum Perks for potential coupons.
• Savings Program: Inquire about copay assistance programs from the manufacturer.

Important Tavneos Interactions and Warnings

Before starting Tavneos, discuss your medical history and all medications, supplements, and foods you consume with your doctor and pharmacist.

• Drug Interactions: Tavneos can interact with several medications, including CYP3A4 inducers, inhibitors, and substrates.
• Alcohol: Alcohol may worsen certain side effects of Tavneos, like nausea, headache, dizziness, diarrhea, and liver problems.
• Grapefruit: Avoid grapefruit and grapefruit juice, as they can increase the risk of side effects.
• Pregnancy and Breastfeeding: The safety of Tavneos during pregnancy and breastfeeding is unknown. It's crucial to discuss birth control needs with your doctor too.

When Tavneos Might Not Be Right for You

Talk to your doctor about your full health history, especially if you have:

• History of hepatitis B or other serious infections, such as tuberculosis (TB)
• Active infections or recurring infections
• Liver disease
• Previous allergic reaction to Tavneos

Exploring Alternatives to Tavneos

If you're interested in other treatment options, discuss these alternatives with your doctor:

• Mycophenolate (CellCept)
• Cyclophosphamide (Cytoxan)
• Rituximab (Rituxan)
• Azathioprine (Imuran)
• Methotrexate (Trexall)

Disclaimer: This article provides general information and shouldn't replace professional medical advice. Always consult with your doctor or healthcare provider before starting any new medication or treatment.